England head coach Eddie Jones has selected two new faces in his 34-man squad that will take part in a training camp in Brighton.
Bath prop Beno Obano and Newcastle Falcons openside flanker Gary Graham have been included in the squad that will be preparing for the Six Nations campaign, which starts with a game against Italy on 4th February in Rome.
England are 4.33 to win the Six Nations outright, while France can be backed at 501.00, Ireland at 1.28 and Scotland at 15.00.
"This camp in Brighton is important for us to set the tone as a squad ahead of the Six Nations," said Jones.
"We will need to improve if we are to hunt down our opponents and beat them. This tournament will be exciting and challenging, as we know we will play against some very strong teams.
"Brighton will provide a great base to begin our preparations with players coming away with a clear plan for our opening match of the campaign against Italy."
Northampton's Courtney Lawes will miss the camp for personal reasons.
England training squad for Brighton camp:
Backs: Mike Brown (Harlequins), Nathan Earle (Saracens), Jonny May (Leicester), Denny Solomona (Sale), Anthony Watson (Bath), Danny Care (Harlequins), Owen Farrell (Saracens), George Ford (Leicester), Piers Francis (Northampton), Jonathan Joseph (Bath), Jack Nowell (Exeter), Henry Slade (Exeter), Ben Te'o (Worcester), Marcus Smith (Harlequins), Ben Youngs (Leicester).
Forwards: Charlie Ewels (Bath), Gary Graham (Newcastle), James Haskell (Wasps), Nick Isiekwe (Saracens), Maro Itoje (Saracens), Joe Launchbury (Wasps), Zach Mercer (Bath), Chris Robshaw (Harlequins), Sam Simmonds (Exeter), Billy Vunipola (Saracens), Dan Cole (Leicester), Tom Dunn (Bath), Jamie George (Saracens), Dylan Hartley (Northampton), Joe Marler (Harlequins), Beno Obano (Bath), Kyle Sinckler (Harlequins), Mako Vunipola (Saracens), Harry Williams (Exeter).
View all Rugby Union betting