Spurs opener for champions City
Manchester City will begin the defence of their Premier League title with a trip to Tottenham on the opening day of the 2021/22 season.
Pep Guardiola's men are 1.66 to retain their top-flight crown having claimed the title by 12 points from runners-up Manchester United, who are 9.00 to win the Premier League outright. Tottenham finished 24 points behind City in the final standings having faded away after a strong start which saw them top the standings in November, but will look to bounce back this time around and are 5.00 for a top four finish.
Spurs got the better of City when they last visited the Tottenham Hotspur Stadium so the champions will need to hit the ground running when they begin their bid for a fourth title in five years on the weekend of 14th/15th August.
City's Manchester rivals United also face a tricky opening day encounter having been paired with rivals Leeds United.
Elsewhere, newly-promoted Norwich City will welcome Liverpool to Carrow Road in what will be the fourth meeting between the sides on the first weekend of a new season, the Reds having won the previous three.
Play-off winners Brentford face a London derby against Arsenal, while fellow promoted outfit Watford play host to Aston Villa.
European champions Chelsea face Crystal Palace at home first up, followed by a trip across the capital to face Arsenal the next weekend. The Blues also face Liverpool at Anfield in a tough opening month.
Other notable dates to look out for include the first Manchester derby of the season on the weekend of 6th/7th November, while Liverpool go to Old Trafford on 23rd October.
The first north London derby of the campaign is due to take place on 25th September, with its Merseyside equivalent on 30th November.