England have been hit by the news that Joe Launchbury has been ruled out of the autumn internationals after undergoing knee surgery.
The lock suffered the setback while captaining Wasps in their 41-35 win over Leicester and has now had an operation to correct the problem.
Launchbury is expected to miss the next 10 to 12 weeks of action, ruling him out of the Red Rose's upcoming Tests.
England are due to host South Africa on Saturday 3rd November, before also taking on New Zealand, Japan and Australia at Twickenham.
The 27-year-old was tipped to start in the second row after impressing in the Six Nations and playing in two of the three Tests during this summer's series against the Springboks.
Wasps have also announced that Dan Robson, who was another who part of the squad that toured South Africa, also faces a spell on the sidelines.
The scrum-half is set to undergo surgery on an ankle problem which is expected to keep him off the field for 12 weeks.
It means the pair will be absent for Wasps' opening four Champions Cup group games against Leinster, Bath and the home and away ties with Toulouse.
Dai Young's side are 1.90 to win with a 16.5 point start in Dublin on Friday, with the reigning champions priced at 1.90 to win with a 16.5 point deficit.
England boss Eddie Jones will have his fingers crossed that no more of his players suffer injuries before he announces his squad next Thursday.
As well as Launchbury and Robson, Bath full-back Anthony Watson and Exeter forward Sam Simmonds are also out of the upcoming matches due to injury.
View all Rugby Union betting