Eddie Jones says England will aim to share the responsibilities of ball carrying in the absence of Billy Vunipola and Nathan Hughes when they face Italy.
Jones' side take on Italy in Rome on Sunday and are 4.33 to win the Six Nations for the third year in a row.
England have named Ben Te'o at outside centre, while Courtney Lawes will play at flanker and Exeter Chiefs forward Sam Simmonds at No 8.
"We've got a fantastic squad that have all prepared really well," said Jones.
"We had a terrific week in Portugal and there are guys competing for spots, so it's been difficult. The great thing about our team is that no one is a certainty. Some players have got more credit than others.
"We've decided to give Ben Te'o a run at 13."
Maro Itoje will partner Joe Launchbury in the second row but Jones is keen to see how England cope without injured duo Vunipola and Hughes.
He added: "It's about spreading the workload. We don't want to rely on one dominant ball carrier because if you rely on one then the opposition find a way to stop that ball carrier and you're stopped going forward."
England team to face Italy:
Brown, Watson, Te'o, Farrell, May, Ford, Youngs, Vunipola, Hartley, Cole, Launchbury, Itoje, Lawes, Robshaw, Simmonds.
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